Can you take mirtazapine for sleep?

November 5, 2020 3 mins read
Can you take mirtazapine for sleep?

After nights, weeks or even months of insomnia and disrupted z’s, could mirtazapine for sleep be the answer?

Mirtazapine has helped many people with insomnia fall asleep at night, but does it really work and should you consider taking it?

What is mirtazapine?

Mirtazapine is a medication that is used to treat depression. It works by increasing the activity of mood-enhancing chemicals called noradrenaline and serotonin in the brain. If you take it, it can improve your mood, as well as your overall sense of wellbeing. It was not created to be used as a sleeping tablet, but it can make you sleepy. It is also sold under the names Remeron, and Zispin SolTab.

Can mirtazapine be taken for sleep?

Mirtazapine is often prescribed to people who struggle with sleep. It is typically prescribed off-label, which means that while it is used for sleep, it has been made and approved to be an antidepressant.

Depression and insomnia often go hand-in-hand, and many people who take antidepressants are also prescribed additional medication to help them sleep. Taking mirtazapine for sleep could help with your symptoms of both depression and insomnia (two birds, one medication).

Doctors will usually prescribe a low dose and increase the dosage as you go on. This medication is generally prescribed in doses of 7,5mg, 15mg, 30mg or 45mg. However, mirtazapine is not equally as effective for all people. Typically, with antidepressants, you might need to try different medications to see which one is the most effective for you.

Mirtazapine side effects

As with most antidepressants and sleeping pills, it is important to educate yourself on the possible side effects. If you take mirtazapine, you can experience side effects, such as:

  • An increased appetite
  • Weight gain
  • Dizziness
  • Feeling drowsy and tired after waking up
  • Having a dry mouth
  • Constipation
  • Frequent headaches
  • Feeling restless

Mirtazapine can make you feel groggy and tired the next day if you take the medication too late at night or if your dosage is too high.

Serious side effects like severe stomach or back pain, thoughts about self-harm, yellow skin or eyes, and fever are extremely rare. As with any antidepressant, you need to track if your depression symptoms start to worsen and if you start to experience suicidal thoughts after starting to take it. You must seek medical attention if you experience one of these side effects.


If you have been diagnosed with depression, and struggle to sleep at night, speak to your doctor about whether mirtazapine will be a good option for you to try.

If other medications for depression and insomnia have failed you, mirtazapine might be the medication that will improve your mood, help you sleep better at night and improve your current quality of life.